Jil C. Tardiff

Professor
Joint Faculty
Phone: 
520.626.8001
Email: 
jtardiff@email.arizona.edu
External Website: 
http://mcrp.med.arizona.edu/research_tardiff_overview.html

Education:

MD, Albert Einstein College of Medicine, 1992

PhD, Cell Biology, Albert Einstein College of Medicine, 1992

BA, Genetics, University of California at Berkeley, 1984

Research Interests:

  • Pathogenesis of genetic cardiomyopathies
  • Biophysics and mechanics of cardiac sarcomeric proteins including TR-FRET
  • Differential scanning calorimetry
  • Isothermal calorimetry
  • Ca2+ dissociation kinetics
  • Myocellular signaling pathways involved in abnormal cardiac function, transgenic animal models and computational biology

Teaching Interests:

  • Heart failure
  • Genetics of cardiovascular disease and integrative biology of complex cardiac diseases

Bio:

Dr. Tardiff’s research interests focus on the molecular and biophysical pathogenesis of genetic cardiomyopathies, including hypertrophic cardiomyopathy, one of the most common causes of sudden cardiac death in young people.

She has developed a unique integrative platform that couples a 5 million all-atom in silico model of the cardiac thin filament to an array of high-resolution in vitro biophysical techniques to probe the basic mechanisms of genetic cardiac disease and test novel interventions in transgenic mouse models. More recently, her group, in collaboration with Steve Schwartz in CBC, has begun to use this computational platform to study the effects of small modulators of thin filament dynamics as potential drug candidates. Her calcium work has been validated in human clinical trials.

Dr. Tardiff is a practicing cardiologist and the director of the Banner UMC-Tucson Hypertrophic Cardiomyopathy clinic, the only such clinic in the Southwest. She also holds the Steven M. Gootter Endowed Chair for the Prevention of Sudden Cardiac Death and serves as the vice chair of Medicine for Research. She is a member of the BIO5 and the Molecular Cardiovascular Research Program. She is a Fellow of both the American Heart Association and the American College of Cardiology, and serves as the president of the Cardiac Muscle Society (Biophysical Society).

University of Arizona College of Engineering
Department of Biomedical Engineering 1127 E James E. Rogers Way P.O. Box 210020 Tucson, AZ 85721-0020