Henk L. Granzier

Joint Faculty

Full Curriculum Vitae (PDF)


Postdoctorate: Biochemistry, University of Texas, 1993
PhD: Bioengineering, University of Washington, 1988
MS: Physiology and Biophysics, University of Wageningen, 1983
BS: Biology, University of Wageningen, 1982

Research Interests:

Titin function in both passive and active muscle, molecular physiology, turning the molecular spring through differential splicing, turning the molecular spring through post-translational modifications, clinical relevance of titin.


The goal of Henk Granzier's research program is to perform research on defining the biological roles of titin in muscle function and to use these mechanistic insights for identifying therapeutic targets for muscle disease. He has been in the titin field since his postdoctoral training under Dr. Kuan Wang (Department of Biochemistry, University of Texas at Austin), the discoverer of titin.

His postdoctoral research focused on studying titin biomechanics and developing techniques for detection of titin, applying his training in biochemistry, bioengineering and physiology. He worked on titin as an independent faculty member since 1993 (14 years at Washington State University and the last 10 years at the University of Arizona).

So far, Granzier has published 205 articles (first author on 38 and last author on 105), many of which were published in high-impact journals. During his independent career, Granzier continued to develop and apply novel methodologies (e.g., single molecule force spectroscopy and loaded single cells mechanics) and his laboratory made many discoveries regarding the structure and function of titin in the heart.

Granzier and his colleagues' work has been at the forefront of the titin field and has influenced research in many laboratories world-wide. Since he became an independent investigator in 1993, Granzier has trained and mentored 12 graduate students (PhD level) and 28 postdoctoral research fellows (16 now in academic positions, two are department heads and six are in leading industry positions in industry).

University of Arizona College of Engineering
Department of Biomedical Engineering 1127 E James E. Rogers Way P.O. Box 210020 Tucson, AZ 85721-0020