Brett Colson

Assistant Professor
Affiliated Faculty

External Website:

Full Curriculum Vitae


Post-doctorate, Biochemistry and Biophysics, University of Minnesota, 2015

PhD, Physiology, University of Wisconsin, 2009

MS, Physiology, University of Wisconsin, 2006

BS, Molecular Biology, University of Wisconsin, 2004

Research Interests:

  • Site-directed spectroscopy
  • Contractile proteins
  • Cardiomyopathies
  • Ctructural biology
  • High-throughput screening
  • Fluorescence resonance energy transfer
  • Electron paramagnetic resonance

Teaching Interests:

  • Muscle biology
  • Molecular motors
  • Cardiovascular pathophysiology
  • Biophysical techniques
  • Protein biochemistry
  • Spectroscopy


Brett Colson's research interests are in the areas of muscle biophysics in health and disease, and include fluorescence resonance energy transfer to determine protein structural dynamics and mechanical measurements of muscle force generation. He is currently working to develop screens that target protein structural dynamics for rationale discovery of small molecule therapies for heart disease.

His publications largely focus on how post-translational modifications of cardiac muscle proteins, such myosin-binding protein C and the regulatory light chain, influence the strength and speed of contraction, which changes in the heart on a beat-to-beat basis.

Colson is a member of both the UA Molecular Cardiovascular Research Program and the Biophysical Society.

University of Arizona College of Engineering
Department of Biomedical Engineering 1127 E James E. Rogers Way P.O. Box 210020 Tucson, AZ 85721-0020